ActiVin® is Generally Recognized As Safe by FEMA

ActiVin® is a far more powerful antioxidant.
The secret to the French Paradox.
What are free radicals?
What are antioxidants?
The all-natural choice.
Backed by extensive original research.
Differences between ActiVin® and other grape seed extracts.
Look for the logo.
References
Frequently Asked Questions About ActiVin^®

ActiVin® is a far more powerful antioxidant.
You've heard that vitamins C, E and beta-carotene are potent antioxidants for good health. Yet, they don't compare to the power of ActiVin® IH636 grape seed extract found in dietary supplements and nutritional foods and beverages. In every research study in which they've been compared (over 10 different tests), ActiVin® has been shown to be a far more powerful antioxidant.

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The secret to the French Paradox.
For years, scientists have studied the phenomenon known as the "French Paradox." The French have a diet filled with saturated fat and cholesterol, yet they have the lowest rate of heart disease of any western society-nearly half that of the U.S. Why? Some scientists believe the answer lies in the red wine the French drink-specifically, the polyphenolic bioflavonoids concentrated inside the grape seeds, which end up in the wine. In fact, that's why some experts believe that red wine is more healthful than white, since red wine is fermented with the seeds while white wine is not.

The polyphenolic bioflavanoids in grape seeds, which include oligomeric proanthocyanidins or "OPCs,"are some of the most powerful antioxidants yet discovered. ActiVin® is a highly concentrated source of OPCs, which delivers the power of these flavonoids in a convenient, alcohol-free form to help your body fight free radicals and the damage they cause.

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What are free radicals?
Free radicals are highly reactive molecules that can destroy cell membranes and damage DNA. They're produced by exercise, smoking, pesticides, pollution, excess sunlight, and even your body's normal process of metabolizing the air you breathe and foods you eat. Many scientists believe that free radicals may be a root cause of more than 60 chronic and degenerative diseases, including certain types of cancer, cataracts, rheumatoid arthritis and heart disease, as well as the aging process itself.

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What are antioxidants?
Antioxidants are powerful compounds that neutralize free radicals and help you maintain a healthy, active life. Some antioxidants are produced by the body. Others, such as vitamins C, E and beta-carotene, as well as polyphenolic bioflavonoids, must be consumed in our daily diet. Which is why eating lots of fruits and vegetables is important, something most people don't do. It's also why taking an antioxidant supplement, especially a supplement containing ActiVin® IH636, is a healthy decision.

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The all-natural choice.
Studies have shown that ActiVin® IH636 is a super antioxidant  far more powerful than vitamins C, E and beta-carotene. It's made by a unique, patented process called ActiPure™, which uses only natural ingredients, the same ingredients found in red wine: water and ethanol. Other grape seed extracts typically use potentially dangerous chemicals such as acetone, methylene chloride and toluene, which can leave residues and strip away many of the nutrients that the ActiPure™ process retains. Not only is ActiVin® safe and healthful to consume, it's environmentally friendly to produce, no toxic chemicals are flushed down the drain and no trees are cut down for their bark.

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Backed by extensive original research.
ActiVin IH636 is unique. It's also the most extensively studied grape seed extract on the market today. Since 1997, more than 90 research presentations, publications and abstracts have reported on the exciting health benefits of ActiVin® and the research keeps piling up. In fact, many of the university studies on ActiVin® are appearing in the literature of other grape seed extracts.

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Differences between ActiVin and other grape seed extracts.
This practice raises concerns because the chemical composition of ActiVin® is quite different from other grape seed extracts. Which means that the research on ActiVin® does not apply to other grape seed extracts. With ActiVin®, you know exactly what benefits you're getting. With other extracts, you may only learn more about the benefits of ActiVin®.

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Look for the logo.
When it comes to quality, safety and potency, insist on ActiVin®. You'll find it in better dietary supplements and nutritional food and beverage products. Look for the ActiVin logo on the label. It's not just about better health, it's about better living.

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References:
1. Perdue, L., The French Paradox and Beyond, Renaissance

2. Renaud, S., et al., "Wine, alcohol, platelets and the French paradox for coronary heart disease," Lancet, 339:1523-1526, 1992.

3. Heart and Stroke Facts: 1995 Statistical Supplement, American Heart Association.

4. Kinsella, J., et al., "Possible mechanisms for the protective role of antioxidants in wine and plant food," Food Technology, April:85-89, 1993.

5. Kuhnau, J., "Flavonoids. A class of semi-essential food components: Their role in human nutrition," Wld. Rev. Nutr. Diet, 24:117- 191, 1976.

6. Ricardo da Silva, J., et al., "Oxygen free radical scavenger capacity in aqueous models of different procyanidins from grape seeds," J. Agric. Food Chem., 39:1549-1552, 1991.

7. Zimmerman, J., "Oxyradical pathophysiology," Adv. Pediatrics, 42:243-302, 1995.

8. Stohs, S., "Synthetic pro-oxidants: drugs, pesticides and other environmental pollutants," In: Ahmed, S., (ed.), Oxidative Stress and Antioxidant Defenses in Biology, Chapman and Hall, New York, 117-180, 1995.

9. Knight, J., "Diseases related to oxygen-derived free radicals," Ann. Clin. Lab. Sci., 25:111-121, 1995.

10. Schalch, W., et al., "Vitamins and carotenoids - a promising approach to reducing the risk of coronary heart disease, cancer and eye disease," In: Armstrong, D., (ed.), Free Radicals in Diagnostic Medicine, Plenum Press, New York, 335-350, 1994.

11. Bagchi D, et al., "Oxygen Free Radical Scavenging Abilities of Vitamins C and E, and a Grape Seed Proanthocyanidin Extract In Vitro", Res. Comm. Mol. Path. and Pharm., 95(2):179-189, 1997.

12. Bagchi D, et al., "Protective Effects of Grape Seed Proanthocyanidins and Selected Antioxidants Against TPA- Induced Hepatic and Brain Lipid Peroxidation and DNA Fragmentation, and Peritoneal Macrophage Activation in Mice", Gen. Pharm., 30(5):771-776, 1998.

13. Data on file, InterHealth Nutraceuticals, Concord, CA 94520.

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